Redox Signaling Molecules

ASEA Founder Verdis Norton was first introduced to redox signaling biochemistry while serving on the board of a Utah biotech company. The company’s preliminary work in redox molecule synthesis had produced promising results, but a lack of funds forced them to shelf the project early.

Convinced of its breakthrough potential, Verdis and a few close partners pooled resources to acquire the discontinued tech and revive the research. ASEA commissioned its own team of medical professionals, scientists, and engineers to advance the technology, conducting a comprehensive safety analysis and producing a scalable method of production for ASEA REDOX Cell Signaling Supplement and future redox signaling products. 

First, it’s important to remember that redox signaling is a natural biological process that safely occurs in every cell of our bodies. The redox signaling molecules in ASEA products are native to the body and easily assimilated. Studies have consistently shown that ASEA’s redox products are safe and effective. See product label for recommended serving amounts by age.

Redox signaling molecules are produced within every cell in your body and act as either cellular messengers or cellular activators.

Redox is scientific shorthand for reduction-oxidation reaction, a biologically important electron-transfer reaction that plays a significant support role in many of the body’s life-sustaining processes, notably energy-providing metabolic functions.

The activator molecules carry the messages that tell your cells to activate antioxidants stored in your body; both activator molecules and antioxidants are naturally occurring and man-made.  Antioxidants keep oxidative free radicals in check and prevent them from causing other cellular damage. However, antioxidants don’t work unless activated by redox signaling molecules.

Messenger molecules are responsible for enabling proper cell communication within your body to ensure optimal performance of the immune system. They also activate your body's immune system to protect against bacteria, viruses, and infection.

The discovery and study of human cells began in the 19th century, but it wasn’t until the latter part of 20th century that cells were understood in enough detail to begin observing and theorizing the forms of signaling behind cell activity. By 1999, the role of redox within cell signaling was understood and formalized enough to prompt the creation of a peer-reviewed scientific journal on the topic.

The processes of metabolism and cellular respiration saw discoveries in the 1930s and ’40s that illuminated the methods by which the human body uses oxygen and redox processes to fuel vital functions. Research in the 1950s and ’60s provided early clues into the molecular basis of cell signaling, though scientific papers didn’t begin talking about cell signaling as a distinct discipline consistently until the ’80s and ’90s.

Redox signaling molecules are produced in every cell of the body through natural metabolic processes. Until the 21st century, such biological processes were the only known source of redox signaling molecules. That changed in the early 2000s, when ASEA developed its groundbreaking, patented process to produce redox signaling molecules from refined salt and purified water—making the first and only supplement on the market verified to contain active redox signaling molecules.

Oxidative stress creates an imbalance between pro-oxidants and antioxidant systems in your body. An imbalance can be a result of several environmental factors such as exposure to pollutants, infections, poor diet, toxins, and radiation. To counter this, your body utilizes redox signaling molecules to communicate and to help maintain a healthy balance between pro-oxidants and antioxidants.

Your health depends on a balance between oxidative stress and antioxidant defenses. As we age, and as stress and environmental toxins inundate our lives and weaken our defenses, normal cellular function declines, and with it, the body’s ability to produce and maintain a proper balance of redox signaling molecules.

Through this process, these molecules support crucial immune system functions, as well as cell renewal and healing at every age, but our ability to utilize these molecules becomes less efficient as we age.

For many years, researchers have explored ways to supplement redox signaling molecules in your body to combat the effects of age, toxins, and environmental stress. ASEA has developed a patented technology that replicates these naturally occurring molecules outside of the body.

Redox Signaling molecules are classified into two groups: Reactive Oxygen Species and Reduced Species. The Reactive Oxygen Species arms the immune system, the Reduced Species activates antioxidants. A careful, homeostatic balance between these two species is maintained in all cells and tissues. When a problem or damage occurs, this balance is disturbed, and this imbalance sends a signal to cause the cells and tissues to defend and repair themselves, thus restoring healthy balance.

Gary Samuelson Ph.D., is the scientist who has succeeded in stabilizing balanced Redox Signaling Molecules outside of the body.  Dr. Samuelson is an Atomic Medical Physicist with expertise in nanotechnology.  Aiming for others to understand this important technology while not require a deep science background; Dr. Samuelson documented his discovery from a high-level perspective, the book "A Journey of Discovery into Redox Signaling Biology" was published in 2018.

Cellular communication is important for overall cellular health. It ensures that messages are delivered and received in a timely manner to continue cell production and repair.

The healthy upkeep of the body depends on communication between cells in every tissue, organ, and system. This vital intercellular communication ensures that messages are delivered and received to modulate cell production, initiate and sustain repair mechanisms, and perform other restorative processes. The molecules involved in this communication are called cell signaling molecules.

During cellular respiration, the body produces small molecules with redox potential. These are redox molecules, and because many of them can perform cell signaling functions, these types of redox molecules constitute their own important class of cell signaling molecules called redox signaling molecules. Any cell signaling function carried out specifically by redox signaling molecules is known as redox signaling.

In 2016, ASEA commissioned a scientific study that used gene expression as the key performance indicator for ASEA REDOX Cell Signaling Supplement. The study found that, over eight weeks, those who drank ASEA REDOX daily experienced a 20–31% beneficial and stable change in gene expression in five genes involved in pathway signaling.

The nucleus is the cellular “brain,” which holds information about the cell’s specialized function in small segments of DNA called genes. Gene expression is the process by which genetic information is accessed and applied to orchestrate cellular function; without it, cells would be unable to perform life-sustaining tasks. The supplemental redox molecules found in ASEA REDOX Cell Signaling Supplement have been shown to affect genetic expression in a positive way, helping to protect, rejuvenate, and enhance cellular function.

A series of chain reactions (or cascades) initiated by signals at the cellular level cue cellular responses that maintain the balanced biological activity that keeps your body functioning. Signaling pathways guide the progression of these cellular responses, including genetic responses, determining their scope and overall effect in the body. Some pathways are extensive and can influence a wide range of physiological behaviors. For example, the genes affected by ASEA REDOX play a significant role in influencing five key areas of health:

• Vascular Health
• Innate Immune System Response
• Inflammation Reduction
• Hormone Modulation
• Digestive Enzyme Production

While most ordinary dietary supplements provide only nutrients the human body does not synthesize, the biological deficiencies caused by aging and cellular breakdown go deeper than just nutrition. As stress, diet, air quality, and other environmental factors cause cellular breakdown over time, the body’s naturally supplied balance of redox signaling molecules is compromised - creating a need for supplemental redox molecules like those found in ASEA REDOX Cell Signaling Supplement.

The body is continuously producing redox signaling molecules, but these molecules aren’t made in the same volume and can be less effective as we get older. Taking redox signaling molecules won’t reduce the amount your body naturally produces.

Yes, each of our bodies is different and has specific needs. With the proper nutrition, exercise and supplements, you can restore and maintain the optimal level of redox signaling molecules, helping you feel more energized and healthier longer. If you're unsure of your health status, have multiple health problems or are pregnant, speak with your doctor before starting a new supplement regimen. Working with your doctor ahead of time is a good way to determine a program that's right for you.

ASEA Patents

Redox signaling is a maturing area of research within the fields of cell biology and metabolic studies. A peer-reviewed scientific journal dedicated to understanding the vital impact of redox processes on human health and disease was established in 1999. Estimates put the number of peer-reviewed papers on the topic somewhere in the tens of thousands. 

• Technical Mechanistics and Fundamental Approach to Study Redox
• Redox & Microbiota: From Skin, Brain to gut
• Redox in the Reproductive System
• Redox, Brain & Neurodegenerative diseases
• Redox in the Cancer
• Redox 2019 Innovations
• Redox 2019 Awards

ASEA Redox Supplement is classified as a dietary supplement in the United States. As a dietary supplement, it is not FDA approved but is FDA regulated. The FDA oversees dietary supplements under a different set of regulations than those covering conventional foods and drug products. Dietary supplement manufacturers and distributors are not required to obtain approval from the FDA before marketing their products.

Before a company sells a dietary supplement, it is responsible for ensuring that the product it manufactures or distributes is safe, that any claims made about the product are not false or misleading, and that the product complies with the Federal Food, Drug, and Cosmetic Act and FDA regulations in all other respects. These laws apply to topical products as well as to foods and supplements.

In addition, the NSF International—a global public health and safety organization that provides food safety and quality assurance services across all food supply chain sectors—certified ASEA’s production center as a GMP (Good Manufacturing Practices) compliant facility. This certification confirms ASEA’s products comply fully with the regulations set forth by the FDA as they relate to the production and testing of dietary supplements with specific standards for safety, quality, and performance.

As a company, ASEA cares deeply about following the guidelines set forth by the FDA and always makes sure to stay up to date with any changes in the regulations or manufacturing practices.